Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

Y Yan; Y Wang; JK Heath; EC Nice; F Caruso

Journal article

Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

Y Yan, Y Wang, JK Heath, EC Nice, F Caruso

Advanced Materials | Published : 2011

DOI: 10.1002/adma.201101609

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Abstract

Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

University of Melbourne Researchers

Joan Heath Author

Frank Caruso Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The authors thank A. P. R. Johnston and J. Cui for assistance with the preparation of Scheme 1. This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes (F.C.) and by the National Health and Medical Research Council (NHMRC) Program Grant 487922 (J.K.H., F.C.).